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Effect of Dietary Copper, Manganese, and Zinc on Nitrogen Equilibrium and Mineral Distribution Subsequent to Trauma in Mature Rats^{1 ,2}

Departments of Nutrition and Animal Sciences, Rutgers University, New Brunswick, New Jersey 08903

Following fracture of the femur, changes in nitrogen retention and mineral tissue concentrations in response to graded levels of dietary copper, manganese, and zinc were investigated. Retained nitrogen and liver copper, manganese, zinc, nitrogen and glycogen were determined prior to trauma and at 48-hour intervals for 8 days posttrauma. The excretion of nitrogen increased, and liver copper, manganese, and zinc decreased, as did liver nitrogen and glycogen in response to fracture. Increasing dietary copper, manganese, or zinc increased liver copper, manganese, or zinc, respectively, and decreased nitrogen loss by traumatized rats. The data suggest that trauma induced a change in the concentrations of liver copper, manganese, and zinc which coincided with changes in liver nitrogen and glycogen. The results indicated that subsequent to femoral fracture, the nutritional requirement for copper, manganese, and zinc for minimal nitrogen loss were higher than the NRC requirements for the mature male rat.

KEY WORDS: • trace elements • trauma • nitrogen equilibrium • copper • manganese • zinc

¹ Paper of the Journal Series, New Jersey Agricultural Experiment Station, Cook College, Rutgers University, New Brunswick. New Jersey 08903; supported in part by Research Grant PHS AG 160-01 and by Biomedical Science Support Grant PHS RR 7058-08.

² Reprint requests should be sent to P. Griminger. Department of Nutrition, Rutgers University.

³ Present address: Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55901.

Manuscript received 14 November 1975.