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Effect of Dietary Chromium on Glucose Tolerance and Serum Cholesterol in Guinea Pigs^{1 ,2}

Department of Agriculture and Natural Resources, Nutrition Research Laboratory, Lincoln University, Jefferson City, Missouri 65101

The effects of feeding three levels of dietary chromium (Cr) to non-pregnant guinea pigs, guinea pigs during pregnancy and lactation and F-1 offspring guinea pigs on weight gain, glucose tolerance, glucose peak time value and serum cholesterol concentration has been investigated. Dietary levels of Cr were: Basal Diet (B) = 0.125 ppm; B supplemented with 0.5 ppm Cr (S₁ Diet) and B supplemented with 50 ppm Cr (S₂ Diet). All groups had similar weight gain patterns and daily feed intake levels. Parent generation guinea pigs fed the B diet consumed less than 10 µg Cr/kg body weight/day while F-1 guinea pigs consumed more than this amount. Mortality rates during pregnancy were greater in guinea pigs fed the B diet than in the Cr supplemented groups suggesting a possible protective effect by Cr. Glucose tolerance, glucose peak time values and serum cholesterol appeared to be more affected by pregnancy and generation of guinea pigs than by the level of dietary Cr. Results suggest that species differences may exist between Cr requirements of guinea pigs and rodents for avoiding glucose intolerance.

KEY WORDS: • chromium • glucose tolerance • serum cholesterol • guinea pig

¹ Supported in part by USDA-CSRC Grant Number 316-15-15.

² Presented at the annual meeting of the Federation of American Societtes of Experimental Biology, Atlantic City, N.J. Federation Proc. 34, 927 (1975).

³ Present address: University of Puerto Rico Medical Science Campus, Dept. Biochemistry & Nutrition, San Juan, Puerto Rico 00936.

⁴ Present address: Colorado State University, Food Science & Nutrition, 236 Aylesworth N.W., Fort Collins, Colo. 80523.

⁵ Present address: Inter American University, Natural Sciences Dept., Hato Rey, Puerto Rico 00919.

⁶ To whom reprint requests should be addressed.

Manuscript received 10 September 1975.