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Journal of Nutrition Vol. 106 No. 1 January 1976, pp. 68-72
Copyright © 1976 by American Society for Nutrition
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Gluconeogenic Response to Mannoheptulose in the Rat1,2,

George J. Klain, A. Wayne Meikle3 and Thomas P. O'Barr4

Letterman Army Institute of Research, Presidio of San Francisco, California 94129

Since administration of mannoheptulose induces temporary hyperglycemia, the present study was conducted to elucidate this phenomenon. The results indicate that mannoheptulose stimulates the activity of hepatic fructose-1,6-diphosphatase and phosphoenolpyruvate carboxykinase, and enhances incorporation of alanine into blood glucose and hepatic glycogen. In addition, mannoheptulose increases plasma levels of glucagon and hepatic cyclic AMP concentration. Gluconeogenic effects of mannoheptulose appear to be mediated by glucagon.

KEY WORDS: • mannoheptulose • liver • gluconeogenesis • glucagon

1 The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

2 In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facillities and Care of the Institutes of Laboratory Animal Resources, National Academy of Sciences-National Research Council.

3 Present address: Division of Metabolism, University of Utah Medical Center, Salt Lake City, Utah 84112.

4 Present address: Division of Clinical Research, Fitzsimons Army Medical Center, Denver, Colorado 80240.

Manuscript received 1 August 1975.




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