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Relative Activity of {alpha}-Tocopherol and {gamma}-Tocopherol in Preventing Oxidative Red Cell Hemolysis

John G. Bieri1, Ritva Poukka Evarts and John J. Gart

Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism and Digestive Diseases, and Biometry Branch, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20014

The purpose of this study was to compare the antioxidant activities of {alpha}-tocopherol and {gamma}-tocopherol in protecting the red cell membrane against lipid peroxidation. Tocopherols were incorporated into the red cell membrane by incubating cells with solutions of the tocopherols in bovine albumin. The cells were then washed and subjected to the dialuric acid hemolysis test. Analysis of variance of the response curves revealed that {gamma}-tocopherol had 38% of the activity of {alpha}-tocopherol. No evidence was found for an interaction between the two tocopherols when present in the red cell membranes simultaneously.

KEY WORDS: • {alpha}-tocopherol • {gamma}-tocopherol • erythrocyte membrane • erythrocyte hemolysis

1 Reprint requests should be addressed: Building 10, Room 5N-102, National Institutes of Health, Bethesda, MD 20014.

Manuscript received 16 June 1975.


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