QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Katz, R. S. Articles by Baker, D. H. Search for Related Content PubMed PubMed Citation Articles by Katz, R. S. Articles by Baker, D. H.

Methionine Toxicity in the Chick: Nutritional and Metabolic Implications

Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

Several assays with young chicks fed crystalline amino acid diets were conducted to investigate the effects of supplemental glycine, serine, threonine, arginine, or adenine on the growth depression resulting from consumption of excess methionine. Glycine was partially effective in alleviating the growth depression caused by excess methionine. The addition of threonine together with glycine improved performance still further. Efficiency of food utilization for weight gain was greater in birds fed the methionine-imbalanced diet supplemented with glycine and threonine than in those fed the control diet. Supplemental glycine, threonine, or adenine, but not arginine, was effective in ameliorating the hypoglycemia resulting from consumption of excess methionine. The rate of oxidation of a tracer dose of threonine was increased markedly by feeding 1.25% excess methionine. This was reflected in a 20% depression in threonine utilization for weight gain as measured by slope ratio. The data suggest that both threonine and glycine are antagonized by consumption of excess methionine.

KEY WORDS: • methionine • threonine • glycine • arginine • homocysteine • adenine • growth • oxidation rate • plasma glucose

¹ Present address: The Quaker Oats Company, 617 West Main Street, Barrington, Ill. 60010.

Manuscript received 6 February 1975.

This article has been cited by other articles:

				M. Xie, S. S. Hou, W. Huang, and H. P. Fan Effect of Excess Methionine and Methionine Hydroxy Analogue on Growth Performance and Plasma Homocysteine of Growing Pekin Ducks Poult. Sci., September 1, 2007; 86(9): 1995 - 1999. [Abstract] [Full Text] [PDF]

				S. Toue, R. Kodama, M. Amao, Y. Kawamata, T. Kimura, and R. Sakai Screening of Toxicity Biomarkers for Methionine Excess in Rats J. Nutr., June 1, 2006; 136(6): 1716S - 1721S. [Abstract] [Full Text] [PDF]