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Journal of Nutrition Vol. 105 No. 8 August 1975, pp. 995-1002
Copyright © 1975 by American Society for Nutrition
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Linoleate Enrichment of Diet and Prostaglandin Metabolism in Rats1

Dong Ho Hwang2, Melvin M. Mathias, Jacqueline Dupont and Donald L. Meyer

Department of Food Science and Nutrition, Colorado State University, Fort Collins, Colorado 80523

Evidence that biosynthesis of prostaglandins (PG) in tissues of animals deficient in essential fatty acids is dependent on the availability of their precursors has been demonstrated. The purpose of this study was to determine the following: (1) effects of dietary linoleate enrichment on PG biosynthesis in rats; (2) effects of exogenous PGE2 and dietary linoleate on plasma free fatty acids and serum cholesterol in fed and fasted rats. Rats were fed three different concentrations of dietary linoleate as beef tallow, hydrogenated vegetable fat, or corn oil. The concentrations of PGE1 and PGF2{alpha} measured by radioimmunoassay were higher in rats fed the corn oil diet than those fed the beef tallow diet independent of energy status. A decrease in the concentration of PG between fasted and fed rats receiving hydrogenated vegetable fat is discussed in respect to the possible influence of trans isomers of unsaturated fatty acids on the biosynthesis of PG. There were significant effects of fasting on serum cholesterol concentration regardless of diet and significant interactions among effects of PGE2, fasting, and diet, suggesting regulatory effects of PGE2 on serum cholesterol concentration. The increase in plasma free fatty acids associated with fasting was prevented by PGE2 for all diets, but had the most marked effect on rats fed hydrogenated vegetable fat.

KEY WORDS: • linoleate • prostaglandins • serum cholesterol • plasma free fatty acids

1 Supported in part by USPHS, NIH grants AM 16097 and KO4 HL 70517.

2 Present address: Department of Food Science, Cornell University, Ithaca, N.Y. 14850.

Manuscript received 2 January 1975.




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