QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mcconnell, K. P. Articles by Hurt, O. J. Search for Related Content PubMed PubMed Citation Articles by Mcconnell, K. P. Articles by Hurt, O. J.

Selenium Levels in Human Blood and Tissues in Health and in Disease^{1, 2,}

Veterans Administration Hospital and University of Louisville School of Medicine, Louisville Kentucky 40202

The levels of selenium in human sera and pancreatic, hepatic, and synovial tissues were measured. An attempt was made to correlate the selenium level with certain disease states. Selenium was determined by neutron activation analysis, using the 17.4 second half-life isotope ^77mSe with a sensitivity of 2 ppb. Serum-bound selenium was determined in normal individuals and individuals with various malignancies, and medical and surgical disorders. Tissue selenium was assayed in diseased and normal pancreases, livers, and synovial membranes. A wide variation was observed both in the serum selenium content of patients with a malignancy and in postmortem pancreatic and synovial tissues showing histopathological changes. Significantly lower selenium values were observed in sera from cancer patients than from normal individuals. Higher values were generally observed in patients with primary neoplasms of the reticuloendothelial system. Higher tissue concentrations were obtained in synovia from patients with rheumatoid arthritis and in pancreatic tissues associated with histopathological changes.

KEY WORDS: • selenium • malignancy • sera • synovial membrane • liver • pancreas

¹ Supported by Veterans Administration Research Funds 821, and in part by Selenium-Tellurium Development Association, Inc.

² Presented in part at the IX International Congress of Nutrition, Mexico City, Mexico, September 1972.

³ Research Chemist, Veterans Administration Hospital, Louisville, Ky., and Professor of Biochemistry, University of Louisville School of Medicine, Louisville, Ky.

⁴ Chief, Clinical Laboratory, Veterans Administration Hospital, Louisville, Ky., and Associate Professor of Pathology, University of Louisville, Louisville, Ky.

⁵ Research Physicist, General Medicine Research, Veterans Administration Hospital, Omaha, Nebr.

⁶ Chief. Orthopedic Section, Veterans Administration Hospital, Louisville, Ky., and Assistant Professor of Surgery, University of Louisville, Louisville, Ky.

Manuscript received 31 January 1975.

This article has been cited by other articles:

				D. Frost Selenium in the environment Science, February 11, 1977; 195(4278): 594 - 595. [PDF]