QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Reddy, B. S. Articles by Wynder, E. L. Search for Related Content PubMed PubMed Citation Articles by Reddy, B. S. Articles by Wynder, E. L.

Effects of High Risk and Low Risk Diets for Colon Carcinogenesis on Fecal Microflora and Steroids in Man^{1, 2,}

Naylor Dana Institute for Disease Prevention, The American Health Foundation, Valhalla, New York 10595

We investigated the effects of a high meat mixed Western diet and a nonmeat diet, representing the dietary pattern of high and low risk areas for colon cancer, respectively, on fecal microflora and on bile acid and neutral sterol patterns in man. The total anaerobic microflora as well as the count of Bacteroides, Bifidobacterium, Peptococcus, and anaerobic Lactobacillus were significantly higher during the period of consumption of a high meat mixed Western diet compared with the nonmeat-diet consumption period. The difference in total fecal bile acid excretion was not significant between the two dietary periods. Fecal excretion of microbially modified bile acids and neutral sterols was decreased when subjects eating a high meat diet transferred to a nonmeat diet. These results support the fact that diet plays a modifying role on the composition of intestinal microflora, bile acids, and neutral sterols.

KEY WORDS: • colon cancer • high meat mixed Western diet • nonmeat diet • fecal microflora • bile acid • neutral sterols

¹ Supported by a grant from the American Health Foundation and in part by PHS grant CA16382-01 from the National Cancer Institute.

² Presented in part at the annual meeting of the American Institute of Nutrition, Atlantic City, N.J., April, 1974.

Manuscript received 4 November 1974.