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Effects of Diets Containing Dried Whey on the Lactase Activity of the Small Intestinal Mucosa and the Contents of the Small Intestine and Cecum of the Pig¹

Department of Meat and Animal Science, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706

Two studies were conducted to establish the effects of dietary lactose supplied from dried whey on the lactase activity in the contents of the small intestine and cecum as well as the mucosa of the small intestine. In the first study, feeding 0, 10, 25, or 40% dried whey for 120 days did not alter the mucosal lactase specific activity (µmoles galactose released/mg protein) in the duodenum, upper jejunum, or lower ileum. In the second study, total lactase activity in the small intestine was estimated from the total activity found in 10-cm segments of each meter of small intestine. Feeding a diet containing 40% whey continuously from weaning at 5 weeks of age or from 12 weeks of age did not alter the total lactase activity of pigs killed at 21 weeks of age. Dietary lactose tended to increase the lactase activity in the contents of the cecum and small intestine, but the increases were not always statistically significant. In the second study, Chester White pigs had approximately threefold greater mucosal lactase activities than that of Hampshires. These two breeds may be suitable models for detailed studies into the relationships between lactase deficiency and lactose intolerance.

KEY WORDS: • lactose • small intestine • cecal contents • lactose • dried whey • pig

¹ Supported by funds from the College of Agricultural and Life Sciences, University of Wisconsin, and the USDA-ARS Animal Science Research Division Cooperative Agreement 12-14-100-10, 910 (44).

Manuscript received 16 September 1974.