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Effect of Supplements of Zinc Salts on the Healing of Incised Wounds in the Rat and Guinea Pig

Department of Surgery, Medical Buildings, University of Aberdeen, Foresterhill, Aberdeen, Scotland

Zinc deficiency affects healing as shown by measurement of two parameters of wound healing in the rat, namely the rate of healing of an excised, granulating wound and the development of tensile strength in an incised wound. The rate of healing of granulating wounds in two species of animals, the rat and the guinea pig, is not affected by the addition of supplements of zinc salts to the normal diet (J. Nutr. 105, 815–821). In this study, the development of tensile strength in incised wounds in rats and guinea pigs was measured at 7 and 14 days after wounding in animals given supplements of zinc salts by either the oral or parenteral route. No difference in tensile strength was observed at these times in the wounds of either rats or guinea pigs given zinc supplements.

KEY WORDS: • tensile strength of wounds • dietary zinc supplements • guinea pigs

¹ Present address: Surgical Ward, Wazir Akbar Khan Hospital, Kabul, Afghanistan.

Manuscript received 11 February 1974.