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Journal of Nutrition Vol. 105 No. 5 May 1975, pp. 624-630
Copyright © 1975 by American Society for Nutrition
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Development of Ceruloplasmin in Pigs during the Neonatal Period1

Irene C. Chang, Tei-Pei Lee and Gennard Matrone

Department of Biochemistry, North Carolina State University, Raleigh, North Carolina 27607

Colostrum-free newborn pigs were raised artificially to investigate the appearance of ceruloplasmin in the serum of piglets. The sensitivity of the p-phenylenediamine oxidase activity assay, commonly used as a measure of ceruloplasmin, has been increased 10-fold. Based on this activity, no evidence was found that this copper protein was present in the serum of baby pigs at birth, although some evidence was obtained that the protein moiety (apoceruloplasmin) was present. Holoceruloplasmin usually became detectable in the serum 10–15 hours after birth. Its concentration increased slowly at first and then at an accelerated rate. The ceruloplasmin in the sera of 2-3-day-old piglets was isolated and compared with that isolated from the serum of adults. Contrary to a previous report, the physical and chemical properties of ceruloplasmin synthesized during the first 3 days of life of the piglet showed no significant difference from that synthesized by the adult.

KEY WORDS: • ceruloplasmin • development • neonatal piglet

1 Contribution from the Schools of Agriculture and Life Sciences and Physical and Mathematical Sciences. Paper no. 4560 in the Journal Series of the North Carolina Agricultural Experiment Station, Raleigh, North Carolina 27607. This work was supported in part by grant no. AM-13055 from the National Institutes of Health.

Manuscript received 27 December 1974.




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