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Journal of Nutrition Vol. 105 No. 5 May 1975, pp. 577-580
Copyright © 1975 by American Society for Nutrition
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Methionine Replacement Value of N-Acetylmethionine and Homocysteinethiolactone Hydrochloride for Growing Rats1,2,

H. E. Amos3,4, G. T. Schelling3, G. A. Digenis5, J. V. Swintosky5, C. O. Little3 and G. E. Mitchell, Jr.3

University of Kentucky, Lexington, Kentucky 40506

The ability of young growing rats to absorb DL-homocysteinethiolactone hydrochloride (HCTL-HCl) and N-acetyl-DL-methionine (NAM) and to use them for growth when fed a methionine-deficient diet was studied. In situ intestinal absorption studies demonstrated that both compounds are readily absorbed. Intestinal half-times were 24 minutes for HCTL-HCl and 44 minutes for NAM. Adding molar equivalents of 0.2 or 0.4% methionine to a 0.2% methionine basal diet fed ad libitum resulted in 28-day gains that were 83.2 and 91.1%, respectively, for HCTL-HCl and 94.6 and 99.8% for NAM of the average gain resulting when DL-methionine was added at equivalent levels. Feed efficiencies were also significantly (P < 0.05) improved over rats fed the basal diet. Increasing the HCTL-HCl addition to 0.6% reduced feed intake and gain but not feed efficiency.

KEY WORDS: • methionine replacements • amino acid substitutes • N-acetylmethionine • homocysteinethiolactone hydrochloride

1 This paper (no. 74-4-76) is published with the approval of the Director of the Kentucky Agricultural Experiment Station.

2 Supported in part by a grant from Smith Kline Animal Health Products, West Chester, Pa. 19380.

3 College of Agriculture, University of Kentucky, Lexington, Ky. 40506.

4 Present address: Richard B. Russell Agricultural Research Center, USDA, ARS, P.O. Box 5677, Athens, Ga. 30601.

5 College of Pharmacy, University of Kentucky, Lexington, Ky. 40506.

Manuscript received 31 October 1974.




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