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Effects of Diet on Lipoprotein Lipase Activity in the Rat^{1, 2,}

The College of Agriculture, University of Minnesota, St. Paul, Minnesota 55101, and The School of Pharmacy, University of Southern California, Los Angeles, California 90033

The effects of diet upon the activities of lipoprotein lipase (LPL) of adipose tissue, skeletal muscle, and heart were studied. Two groups of rats were fed diets high in carbohydrate or high in fat for 14 days. Another group was fed a stock diet and fasted 18–20 hours prior to the determination of tissue LPL activity. In the carbohydrate-fed rats, LPL activity was high in adipose tissue (14.78 ± 1.30 units) and low in skeletal muscle (8.47 ± 0.85 units) and heart (9.71 ± 0.94 units), whereas in fasted rats, LPL activity was high in skeletal muscle (15.41 ± 1.98 units) and heart (18.99 ± 0.97 units) and low in adipose tissue (3.29 ± 0.87 units). In fat-fed rats LPL activity was intermediate in adipose tissue (7.93 ± 0.62 units) and high in skeletal muscle (14.44 ± 0.86 units) and heart (15.07 ± 1.12 units). These results suggest that removal processes may be important factors in the response to diet of the kinetics of chylomicron and very low density lipoprotein triglyceride metabolism, and that skeletal muscle may play an important role in the process.

KEY WORDS: • lipoprotein lipase • diet

¹ Supported by a grant (HL-13614-NTN) from the National Heart and Lung Institute, U.S. Public Health Service.

² These data were submitted in part to the Faculty of the Graduate School, University of Minnesota, in partial fulfillment of the Master's Degree (C.L.W.D.).

³ Present address: Nutritionist, Olmsted Medical Group, 210 S.E. 9th St., Rochester, Minn. 55901.

⁴ Present address: Department of Community Medicine and International Health, School of Medicine, Georgetown University, Washington, D.C. 20007.

Manuscript received 6 September 1974.

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