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Life-term Studies in Rats: Effects of Aluminum, Barium, Beryllium, and Tungsten¹

Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03755, and Brattleboro Memorial Hospital, Brattleboro, Vermont 05301

Recondite toxicities of small doses of aluminum, barium, beryllium, and tungsten were evaluated by feeding weanling rats each metal in drinking water for life. Three hundred and thirty-four rats of the Long-Evans strain were divided by sex. Their drinking water contained 5 ppm soluble salts of aluminum, barium, beryllium, or tungsten in a basal water containing zinc, copper, manganese, cobalt, molybdenum, and chromium. The diet fed was low in trace elements. These metals were virtually innocuous as measured by median life-span, longevity, incidence of tumors, serum cholesterol, glucose, and uric acid. There was slight enhancement of growth from tungsten and barium and slight depression from beryllium. There was also slight shortening of longevity from tungsten. At this dose level these metals had little detectable effects in rats.

KEY WORDS: • trace elements • trace metals • life-term studies • toxicity

¹ Supported by Public Health Service Research Grant ES-00699-15. National Institutes of Health, CIBA-GEIGY Corporation. Cooper Laboratories Inc., and Foremost-McKesson Foundation, Inc.

² Present address: 9 Belmont Avenue, Brattleboro, Vt. 05301.

Manuscript received 12 August 1974.