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Ornithine Decarboxylase Activity in Regenerating Liver from Rats Adapted to Controlled Feeding Schedules

Istituto di Chimica Biologica dell'Università di Bologna, Via Irnerio, 48-40126 Bologna, Italy

Ornithine decarboxylase activity was studied during the early phases of liver regeneration after partial hepatectomy in rats adapted to controlled feeding schedules (food available 8 hours per day). Liver ornithine decarboxylase activity exhibited marked daily oscillations during liver regeneration. The time of day of surgery affected the pattern of enzyme activity after partial hepatectomy. A first postoperative peak of activity was constantly found 6 hours after surgery. Another peak of activity was observed near the end of the dark period independent of the timing of the operation. Food intake was found to induce a further peak of activity during the feeding period. Due to the interaction between controlled feeding schedules and partial hepatectomy, the timing of the operation was found to be essential to obtain a better resolution of the different peaks of activity in our experimental conditions.

KEY WORDS: • regenerating liver • partial hepatectomy • ornithine decarboxylase • controlled feeding schedules • diurnal variations

Manuscript received 15 July 1974.