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Acetylmethionine as a Source of Methionine for the Rat

The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45247

N-Acetyl-L-methionine and N-acetyl-D-methionine were compared with L-methionine and D-methionine as sources of methionine. These derivatives were added to a sulfur amino acid-limited diet containing 10% soybean protein isolate. Weight gains, food intake, and protein efficiency ratios (PER) were determined in growing rats. N-Acetyl-L-methionine, L-methionine, and D-methionine produced an equivalent growth response and increase in PER above that of the basal diet. There was no response to supplementation with N-acetyl-D-methionine. An equivalent maximum growth response of rats fed L-methionine or N-acetyl-L-methionine was obtained when the total dietary sulfur amino acids comprised 0.36–0.41% of the diet. The nutritional similarities of methionine and N-acetyl-L-methionine suggest that the latter may be useful as a supplement to diets containing vegetable proteins that are deficient in sulfur amino acids.

KEY WORDS: • L-methionine • D-methionine • N-acetyl-L-methionine • N-acetyl-D-methionine • amino acid supplementation

Manuscript received 16 August 1974.

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