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Lipogenesis and Glyceride Synthesis in the Rat: Response to Diet and Exercise^1,2,

Letterman Army Institute of Research Presidio of San Francisco, California 94129

The responses of hepatic and adipose tissue malic enzyme (ME), citrate cleavage enzyme (CCE), glucose-6-phosphate dehydrogenase (G6PD), and glyceride synthetase (GS) to exercise training and exhaustive exercise and the potential of a high fat or high carbohydrate diet to modify these responses were studied in male Carworth rats. Characteristic elevation and depression of ME, CCE, and G6PD were observed in rats fed the high carbohydrate and high fat diets, respectively. GS was decreased in skeletal muscle, liver, and adipose tissues of high carbohydrate-fed rats. A significant two-way diet-training interaction was indicated for hepatic ME and G6PD. This interaction resulted from an apparent training modulation of ME and G6PD responses to the high fat and high carbohydrate diets. Adipose tissue G6PD was significantly decreased by training. Exhaustive exercise performed immediately prior to sacrifice did not significantly alter ME or CCE activities in either liver or adipose tissues, but decreased adipose tissue G6PD in untrained rats. Exhaustion was also associated with decreased GS activity in muscle and liver. Physical training was associated with a significant increase in GS in muscle and adipose tissues. In contrast to glyceride synthesis, no increase in adipose tissue lipogenic potential was noted in response to training, indicating that the physically trained rat may have an enhanced ability to store but not synthesize fatty acids.

KEY WORDS: • rat liver enzymes • adipose tissue enzymes • muscle enzymes • exercise • exhaustion • diet • lipogenesis • glyceride synthesis

¹ The opinions or assertations contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

² In conducting the research described in this report, the investigators adhered to the Guide for Laboratory Animals Facilities and Care, as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences-National Research Council.

³ Present address: East Carolina University, School of Medicine, Greenville, N.C. 27834.

⁴ Present address: University of California, Department of Chemistry, Riverside, Calif. 92502.

⁵ Present address: National Dairy Council, 111 N. Canal St., Chicago, Ill. 60606.

⁶ Present address: The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Md. 21205.

Manuscript received 13 June 1974.

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