Journal of Nutrition Animal Diets/Enrichment Products...

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Nickel Deficiency in Rats1

Forrest H. Nielsen2, Duane R. Myron3, Samuel H. Givand3, Thomas J. Zimmerman3 and Dwayne A. Ollerich4

United States Department of Agriculture, Agricultural Research Service, Human Nutrition Laboratory, and Departments of Biochemistry and Anatomy, University of North Dokota, Grand Forks, North Dakota 58201

Nickel deficiency was produced in rats fed diet (containing 2–15 ng of nickel/g) based on dried skim milk, acid-washed ground corn, EDTA-extracted soy protein, and corn oil. Controls were fed a supplemental 3 µg of nickel/g of diet as NiCl3·6H2O. The rats were raised in plastic cages located inside laminar flow racks. Nickel deprivation resulted in several consistent pathological findings. These included: (1) increased perinatal mortality, (2) unthriftiness in young rats characterized by a rough coat and/or uneven hair development, (3) altered gross appearance (color) of the liver, (4) increased rate of {alpha}-glycerophosphate oxidation by liver homogenates, (5) decreased liver cholesterol, and (6) ultrastructural changes in the liver with the most obvious difference in the amount and organization of the rough endoplasmic reticulum. Nickel deficiency in rats tended to decrease growth, hematocrits, and liver total lipids and phospholipids.

KEY WORDS: • nickel • trace element • liver ultrastructure

1 Supported in part by the USDA Cooperative Agreement no. 12-14-100-11, 176 (61) amend. 1.

2 Research Chemist, United States Department of Agriculture, Agricultural Research Service, Human Nutrition Laboratory, Grand Forks, N.D.

3 Department of Biochemistry, University of North Dakota, Grand Forks, N.D.

4 Department of Anatomy, University of North Dakota, Grand Forks, N.D.

Manuscript received 25 April 1975.




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Copyright © 1975 by American Society for Nutrition