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Energy Wastage in Rats Given Drugs That Induce Microsomal Enzymes¹

Section of Liver Disease and Nutrition, Veterans Administration Hospital, Bronx, New York, and Department of Medicine, Mt. Sinai School of Medicine of the City University of New York, New York 10468

Metabolic efficiency was studied in rats given drugs known to induce hepatic microsomal enzymes. The presence of an increased metabolic rate was indicated by increases in oxygen consumption under various experimental conditions and by changes in body weight. The latter was not accounted for by increased losses of energy in excreta. The results support the hypothesis that hepatic microsomal enzyme induction can significantly alter the body's metabolic efficiency.

KEY WORDS: • drug metabolism • hepatic metabolism • microsomes • enzyme induction • energy • alcohol

¹ This investigation was supported in part by USPHS grants AA-00224 and AM-12511, and the Veterans Administration.

² Address for reprints: C. S. Lieber, M.D., Section of Liver Disease and Nutrition, Veterans Administration Hospital, 130 West Kingsbridge Road, Bronx, N.Y. 10468.

Manuscript received 21 April 1975.