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Journal of Nutrition Vol. 105 No. 11 November 1975, pp. 1433-1439
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Effects of High Carbohydrate, High Fat, or High Protein Diets on Glucose Oxidation by Isolated Intestinal Epithelial Cells of the Chick

Krishan L. Raheja1, Jay Tepperman2 and Helen M. Tepperman

Department of Pharmacology, State University of New York Upstate Medical Center, Syracuse, New York 13210

A parallel study of 3-O-methyl glucose transport by everted intestinal sacs and [U-14C]glucose oxidation by isolated, dispersed intestinal cells was done in chicks (1) adapted to a high carbohydrate (HC), high fat (HF), or high protein (HP) diet for 2 weeks or (2) fasted up to 5 days. HF and HP diets significantly decreased both serosal:mucosal (S:M) distribution ratios of 3-O-methyl glucose by everted sacs and glucose oxidation by dispersed cells. The effects were more pronounced in HF diet-fed chicks. Fasting significantly increased the S:M ratio throughout a 5-day fasting period, whereas glucose oxidation was increased after a 1-day fast and was decreased after a 5-day fast. Feeding HC diet for 1 week to chicks adapted to HF diet restored both functions to control levels. Refeeding fasted chicks for 3 days also restored S:M ratio to control levels. Histological examination of tissues from various treatment groups revealed no obvious morphological differences. These results suggest that the functional changes described represent adaptive changes at the cellular level and that these changes are readily reversible.

KEY WORDS: • high carbohydrate diet • high fat diet • high protein diet • fasting • refeeding • glucose oxidation

1 Present address: Veterans Administration Hospital, Syracuse, N.Y. 13210.

2 Aided by grant AM 5410 from the National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health.

Manuscript received 20 March 1975.




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