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Journal of Nutrition Vol. 105 No. 11 November 1975, pp. 1371-1376
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Effects of Pyridoxine Deficiency on the Composition of Plasma and Liver Fatty Acids in Rats Fed Low and High Fat Diets1

Pierre E. Dussault and Marius Lepage

Centre de Recherche sur les Maladies Lipidiques, Department of Biochemistry, Faculty of Medicine, Laval University, Quebec City, Canada

A study was made of the effect of pyridoxine deficiency on the fatty acids of liver and plasma in rats fed diets containing 1, 10, or 20% fat. Both ad libitum-fed and pair-fed control rats were used. In pyridoxine deficiency, arachidonic acid decreased with a concomitant increase in linoleic acid. Incubations of liver slices with [1-14C]acetate showed no significant alteration of fatty acid synthesis in pyridoxine-deficient rats fed 1 or 10% fat when compared with the ad libitum-fed control rats, but revealed a marked increase in cholesterogenesis compared with either control group. Incubations with [1-14C]linoleate resulted in no differences in the synthesis of arachidonate between the experimental and the ad libitum-fed control rats. Incubations with [5,6,8,9,11,12,14,15-3H]arachidonate showed decreased incorporation of this fatty acid in total liver lipids in pyridoxine-deficient rats compared with ad libitum fed control rats. We concluded that the diminution in arachidonate observed in liver lipids of pyridoxine-deficient rats does not result from a lower conversion of linoleate into arachidonate, but possibly from an increased degradation of this fatty acid.

KEY WORDS: • pyridoxine deficiency • arachidonate • fatty acids • liver lipids

1 Supported by grants from the Medical Research Council of Canada and from the Ministère de l'Education du Québec.

Manuscript received 25 October 1974.




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