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St. Vincent's Hospital, Montclair, New Jersey 07042
The effect of increasing dietary linoleate upon in vivo platelet aggregation and disaggregation in 20 males and 46 female adult humans was studied. Increasing exogenous linoleate for 2 weeks from 2.89 ± 0.11 to 5.00 ± 0.26% of energy was associated with the doubling of the aggregation time and halving of the disaggregation time. Decreasing dietary linoleate in the following 2-week feeding period was associated with a reversal of the effect.
KEY WORDS: platelet function dietary linoleate serum cholesterol serum triglycerides
1 This work was supported in part by a grant from the Charles Edison Fund.
Manuscript received 24 February 1975.
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