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Influence of Fat and Fluoride on Gastric Emptying of Rats¹

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

The purpose of the study was to investigate the mechanism by which a high fat diet fed to rats enhances the toxicity of dietary fluoride. This phenomenon was pursued by giving ¹⁴C-tripalmitin or ¹⁴C-palmitate in various test meals. The appearance of ¹⁴CO₂ was greatly retarded when fluoride was included. By monitoring the passage of several ¹⁴C-substrates through the gastrointestinal tract, fluoride in the presence of fat was found to cause delayed gastric emptying. This effect likely accounts for the increased toxicity of fluoride to rats fed high fat diets. Little or no effect of fluoride was observed on gastric emptying of fat-free test meals.

KEY WORDS: • fluoride • gastric emptying

¹ Supported in part by a research grant from the Aluminum Co. of America, Aluminum Co. of Canada, Kennecott Copper Corp. Monsanto Chemical Co., Ormet Corp., Eastalco Aluminum Co., Stauffer Chemical Co., Reynolds Metals Co., Kalser Aluminum and Chemical Corp., Anaconda Aluminum Co., Martin Marietta, U. S. Steel Corp., Intalco Aluminum Corp., National Southwire Aluminum Co., and in part by U. S. Public Health Service Grant AM-15521.

Manuscript received 26 December 1973.