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Influence of Dietary Protein on 6- and 9-Desaturation of Fatty Acids in Rats of Different Ages and in Different Seasons¹

Cátedra de Bioquímica, Instituto de Fisiología, Facultad de Ciencias Médicas, U.N.L.P., Calle 60 y 120, La Plata, Argentina

The effect of casein diets on the activity of linoleic acid desaturation to -linolenic acid by rat liver microsomes was studied. An increase in the enzymatic activity was shown to be produced when either linoleoyl-CoA or free acid were incubated with ATP, CoA, and NADH. The amount of protein needed to enhance the desaturation of linoleic acid must be of the order of 35% or higher. Protein-rich diets modified the V_max of the reaction but not the K_m. The 6-desaturation of linoleic acid and -linolenic acid decreased, but the 9-desaturation of stearic acid increased with age of the animal. Besides, the response to dietary protein was higher in old rats than in young ones. A seasonal change was also found. In summer, the 6- and 9-desaturations were significantly reduced and the activating effect of protein was also reduced.

KEY WORDS: • protein diet • fatty acid desaturation • age • seasonal change

¹ Supported in part by the Secretaria de Salud Públiea de la Nación. Argentina, the Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina, and the Comisión de Investigaciones Cientificas de la Universidad Nacional de La Plata.

² Member of the Carrera del Investigador of the Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina.

Manuscript received 21 January 1974.

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