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In vivo Intestinal Absorption of Hexose in Growth-retarded Suckling Rat Pups¹

Gastroenterology Research Laboratory, Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242

Growth retardation (GR) was induced by increasing litter size to 16 to 18 pups on the second day after delivery. Absorption of 3-O-methyl-D-glucose (3MG) was measured in the jejunum + ileum of GR and control (C, 7 to 9/litter) pups using an in vivo perfusion technique under steady state conditions. At 7 to 8 days of age, size of the jejunum + ileum and mean (±SE) rate of absorption of 3MG normalized for intestinal size (mg/g jejunum + ileum dry weight per hour) were similar in GR (65 ± 3) and C (54 ± 9) pups. At 14 to 15 days of age, although intestinal size was smaller in GR than in C, rate of absorption of 3MG was about twofold and significantly higher in GR (126 ± 11) than C (74 ± 4) pups. At 21 to 22 days, submaximal absorption rates from a 10 mg/ml solution were similar in GR (225 ± 11) and C (222 ± 20), but from a 15 mg/ml solution were significantly lower in GR (240 ± 25) than in C (295 ± 18) pups.

KEY WORDS: • growth retardation • neonatal • glucose absorption • intestine

¹ Supported in part by Nutrition Foundation Grant no. 451 and Research Grant AM-02534 of the NIAMDD NIH.

² Recipient of an NIH Academic Career Development Award in Digestive Diseases—Nutrition, AM-70211.

Manuscript received 11 September 1973.