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Effect of Selenite on the Toxicity of Dietary Methyl Mercury and Mercuric Chloride in the Rat¹

Department of Biochemistry, North Carolina State University, Raleigh, North Carolina 27607

Diets containing methyl mercury and mercuric chloride were fed to rats with and without sodium selenite supplements. Effects of selenite-mercury interactions for both forms of mercury include enhancement of the growth rate over that observed on diets with comparable levels of mercury without selenite, altered tissue mercury levels, and altered percentage distribution of mercury among several tissues. In addition, selenite protected against mortality and neurotoxicity due to dietary methyl mercury. Possible mechanisms for the mercury-selenium interactions are discussed.

KEY WORDS: • selenium • mercury • methyl mercury • interactions

¹ From the Department of Biochemistry, School of Agriculture and Life Sciences, and School of Physical and Mathematical Sciences, North Carolina State University, Raleigh, N. C. Paper no. 4169 of the Journal Series of the North Carolina State University Agricultural Experiment Station, Raleigh, N. C. 27607. Supported in part by a grant from the Herman Frasch Foundation. A preliminary report of this work was presented at the 57th annual meeting of the Federation of American Societies for Experimental Biology, April 15–20, 1973, Atlantic City, N. J. Federation Proc. 32, 929A (abstr.).

Manuscript received 14 September 1973.

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