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Influence of Linoleate on Cholesterol Turnover in Rats

Nobuko Iritani and Junko Nogi

Tezukayama-Gakuin College, Sumiyoshi-ku, Osaka 558, Japan

The oral administration of linoleate to rats fed a fat-free diet increased the half-life of cholesterol to 1.7 and 1.5 times greater than the half-life when oleate or palmitate were administered. Plasma cholesterol, however, was significantly lowered by the oral administration of linoleate compared to administration of oleate. After the injection of cholesterol-3H, the total amount of cholesterol and its metabolites, and the amount of radioactivity excreted in the feces was higher in the oleate group than in the linoleate group. But the excretions into bile were not influenced by feeding linoleate. The major fecal metabolites, coprostanol and hyodeoxycholic acid, formed by intestinal microflora, were decreased by feeding linoleate, compared to feeding oleate. The long half-life of cholesterol in the linoleate group may be caused by the increased reabsorption of cholesterol and the secondary effect of linoleate on the multiplication of intestinal microorganisms. On the other hand, oral administration of linoleate rather than feeding an equivalent amount of lard had no effect on the half-life of cholesterol and its metabolites in rats fed a diet containing 5% fat. Therefore, dietary fat might have an influence on the effects of linoleate on cholesterol metabolism.

KEY WORDS: • linoleate • cholesterol turnover • plasma cholesterol • dietary fat

Manuscript received 20 August 1973.




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