QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Klain, G. J. Articles by Meikle, A. W. Search for Related Content PubMed PubMed Citation Articles by Klain, G. J. Articles by Meikle, A. W.

Mannoheptulose and Fatty Acid Synthesis in the Rat^{1 ,2}

Physiology Division, U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons Army Medical Center, Denver, Colorado 80240

Since metabolic alterations induced by mannoheptulose appear to affect fatty acid synthesis, the present study was conducted to elucidate this relationship. The results indicate that mannoheptulose suppresses hepatic fatty acid synthesis as indicated by a reduced incorporation of glucose-³⁴C into fatty acids and by a decreased activity of acetyl CoA carboxylase. Fatty acid synthesis was restored by exogenous insulin. Mannoheptulose had no effect on the activity of several other lipogenic enzymes and did not affect adipose tissue fatty acid synthesis. The effect of mannoheptulose in the liver appears to be mediated by glucagon.

KEY WORDS: • mannoheptulose • fatty acid synthesis • acetyl CoA carboxylase • liver

¹ The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

² In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institutes of Laboratory Animal Resources, National Academy of Sciences-National Research Council.

³ Present address: Division of Metabolism, University of Utah Medical Center, Salt Lake City, Utah 84112.

Manuscript received 1 October 1973.