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Plasma Amino Acids and Stomach Contents of Rats Fed Casein and the Corresponding Amino Acid Mixture

Department of Biochemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., 962 Kashima-cho, Higashiyodogawa-ku, Osaka, Japan

This study with rats was conducted to make clear the cause of lower intake of the diet containing the amino acid mixture simulating casein in place of intact casein in ad libitum feeding experiments. Comparing with the rats force-fed casein diet, those force-fed amino acid diet showed higher essential amino acid concentrations in plasma at 1 and 2 hours after the feeding. The changes in the concentrations, however, appeared to be not so abnormal as to depress the intake of amino acid diet. On the other hand, the stomach contents of the amino acid group, especially the volume of water, at 2, 3 and 6 hours after the feeding were much greater. The stomach distension was also observed to reduce actually the subsequent food intake. When mixtures of amino acid and casein diets in variable ratios were force-fed, there was a parallel relationship between the stomach distension and the proportion of amino acid diet in the mixed diet. However, the voluntary intakes of the mixed diets containing amino acid diet in ratios of 75, 50 and 25% were the same as that of casein diet. These data confirm that the stomach distension of rats fed amino acid diet is one of the major factors of low food intake when the stomach distension exceeds a certain magnitude.

KEY WORDS: • dietary amino acid mixture • plasma amino acids • stomach contents

Manuscript received 9 July 1973.