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Journal of Nutrition Vol. 104 No. 2 February 1974, pp. 223-226
Copyright © 1974 by American Society for Nutrition
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Triglyceride Secretion Rates: Use of Triton WR 1339 in the Rhesus Monkey1

Robert H. Fiser, Jr., Joseph C. Denniston, Russell B. Rindsig and William R. Beisel

Department of Pediatrics, UCLA School of Medicine, Harbor General Hospital, 1000 West Carson Street, Torrance, California 90509 and U. S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

The effects of Triton WR 1339 on plasma lipids were studied in fasted and glucose-loaded rhesus monkeys. This compound produced a marked linear increase in plasma triglycerides (TG) during the first 4 hours of a 5-hour study period. Triglyceride secretion rates were determined in fasted (0.113 ± 0.016 mg TG/kg/min) (mean ± SEM) and in glucose-loaded (0.101 ± 0.019) monkeys. Free fatty acid values (FFA) were depressed, while cholesterol and phospholipid values were unchanged. No evidence of hepatocellular or other tissue damage was noted at necropsy. These studies suggest that Triton administration is valuable in assessing rates of basal hepatic TG secretion in the rhesus monkey.

KEY WORDS: • triton WR 1339 • rhesus monkey • FFA • triglyceride

1 In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences-National Research Council. The facilities are fully accredited by the American Association of Accreditation of Laboratory Animal Care.

Manuscript received 26 June 1973.




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