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Hyperlipidemia in Offspring of Iron-deficient Rats

Nutrition Program, Pennsylvania State University, University Park, Pennsylvania 16802

The effects of maternal dietary iron restriction during gestation and/or lactation on serum lipids in offspring were studied in rats fed diets containing 307 ppm or 5 ppm of iron. At parturition, dams fed the iron-deficient diet and their newborn had tissue reserves of iron and hematocrit values significantly lower than groups fed the control diet. However, serum iron and total iron-binding capacity were similar in both groups. Storage iron was also lower at the end of lactation in both dams and their litters when the dam was fed an iron-deficient diet during gestation and lactation than when a control diet was fed in either or both periods. Pups of dams fed the deficient diet during both gestation and lactation had lipemic sera characterized by elevated triglycerides, cholesterol and phospholipids. In pups of dams fed a deficient diet during one period and control during the other or control during both periods, lipid values were significantly lower. No differences in serum lipids were found among groups of dams.

KEY WORDS: • iron deficiency • lipemia • hyperlipoproteinemia • triglyceride • cholesterol • phospholipids

Manuscript received 15 March 1974.