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Influence of Dietary Lipids on Plasma and Hepatic Lipids and on Blood Clotting Properties in Rats Fed Oral Contraceptives^{1 ,2}

Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907

Effects of three oral contraceptives (OC): En, Pr and Ov, on plasma and hepatic lipids and blood clotting properties were studied in intact and ovariectomized rats fed diets containing 20% (by weight) safflower or coconut oil with and without cholesterol (0.5%). Diets were fed ad libitum from weaning until 6 months of age. Oral contraceptives were mixed with the diet during the last 28 days of the experiment. Rats fed En and Ov ate less than others but only animals fed coconut oil weighed less at the end of the experiment. Food intake and body weight increased as a result of ovariectomy. Plasma fibrinogen was increased by Pr, En, cholesterol and by the interaction of Ov and ovariectomy whereas fibrinolytic activity was depressed by coconut oil, Ov and ovariectomy. Prothrombin rate was elevated by ovariectomy and the interaction of cholesterol, coconut oil and any OC. Plasma triglycerides were elevated by the interaction of any OC and coconut oil whereas plasma cholesterol was depressed by any OC and elevated by dietary cholesterol. Liver lipids were increased by the interaction of cholesterol, all OC and safflower oil and by ovariectomy. Dietary lipids significantly influenced certain actions of OC on blood clotting properties and on plasma and hepatic lipids.

KEY WORDS: • oral contraceptives • lipids • blood clotting

¹ From Purdue University Agricultural Experiment Station and School of Home Economics, Department of Foods and Nutrition, Lafayette, Indiana 47907. Journal paper 4953. The data were taken from a thesis submitted by Mary H. Tabacchi in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Purdue University.

² A preliminary report was presented at the Meeting of the Federation for Experimental Biology in Atlantic City, N. J., April 1972; Federation Proc. 31: 701 (abstr.).

³ Present address: Department of Human Nutrition 3 and Foods, Cornell University, Ithaca, N. Y. 14850.

Manuscript received 18 December 1972.

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