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Maltose in Total Parenteral Nutrition of Rats

McGaw Laboratories, Division of American Hospital Supply Corporation, 1015 Grandview Avenue, Glendale, California 91201

Parallel studies designed to compare the utilization of maltose to dextrose were performed in rats using total parenteral feeding techniques. Two groups of rats comparable in age and size were fed intravenously for 2 weeks hypertonic nutrient solutions containing 25% carbohydrate, 4.25% crystalline amino acids, and maintenance levels of electrolytes and vitamins. The control group was given a solution containing 25% dextrose, the test group received isocaloric quantities of solution containing maltose. Weight, fluid balance, and urinary sugar content were followed in each animal. The dextrose-infused control animals maintained their weight and excreted little or no dextrose; maltose-infused rats lost an average of 25% of their body weight and excreted approximately 50% of the infused carbohydrate. It is concluded that maltose cannot serve as a total substitute for glucose in total parenteral nutrition in rats.

KEY WORDS: • maltose • total parenteral nutrition

Manuscript received 18 October 1972.