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Diurnal Changes in the Fatty Acid Patterns of Rat Liver Lipids¹

Department of Nutritional Sciences, University of Wisconsin-Madison, Wisconsin 53706

Certain changes in the fatty acid composition of liver lipids could be related to diurnal cycles. To examine this, the fatty acid profiles of liver triglycerides, phospholipids and cholesterol esters were determined at 6-hour intervals using rats fed a high fat (corn oil) diet either ad libitum or hourly, one twenty-fourth of the food consumed by the former group. Diurnal changes were most prominent in the triglyceride fraction, and in the ad libitum-fed group reflected the pattern of dietary intake. One cycle, affecting linoleate and arachidonate, was on an 18–6 hour basis and the second, primarily affecting palmitate, was uniform with 12-hour phases. The maxima were displaced 12 and 6 hours, respectively, by hourly feeding and may be related to the light cycle. Consistent in both groups and in all fractions was the increase in arachidonate towards the end of the light period.

KEY WORDS: • diurnal • fatty acid profile • liver lipids

¹ Research supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison and is a contribution of N-C 95.

² Home Economics Department, Northern Illinois University, DeKalb, Ill. 60115.

³ To whom correspondence should be addressed.

Manuscript received 10 November 1972.