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Effect of Bound Gossypol on the Absorption of Iron by Rats^1,2,

Department of Animal Science, North Carolina State University, Raleigh, North Carolina 27607

The absorption of iron is decreased when bound gossypol is fed to rats. When 0.005, 0.12, 0.24, and 0.35% dietary bound gossypol was fed, iron absorption decreased linearly as the bound gossypol increased. As the level of dietary iron increased, iron absorption increased when expressed in microgram quantities and decreased when expressed as a percentage of the dietary iron ingested. Both free and bound gossypol in the liver increased with increases in dietary bound gossypol and decreased with increasing levels of dietary iron.

KEY WORDS: • gossypol • iron • absorption • rat

¹ Supported in part by Public Health Service Grant no. AM-07039. It is Paper no. 3902 of the Journal Series of the North Carolina State University Experiment Station, Raleigh, N. C. Use of trade names in this publication does not imply endorsement of the products mentioned.

² The material in this paper will be presented to the graduate faculty of North Carolina State University by D. L. Herman in partial fulfillment of the requirement for the degree of Master of Science, Department of Animal Science.

Manuscript received 6 November 1972.