Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diorio, L. P.
Right arrow Articles by Navia, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diorio, L. P.
Right arrow Articles by Navia, J. M.

The Separate Effects of Protein and Calorie Malnutrition on the Development and Growth of Rat Bones and Teeth1

Louis P. Diorio2, Sanford A. Miller and Juan M. Navia3

Massachusetts Institute of Technology, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139

The effects of a specific protein malnutrition on the growth and development of rat teeth as well as bones were studied. The nutritional stress was imposed during the suckling period which is the time when first and second molars are actively mineralizing. Rat dams were fed a low protein (7%) diet so as to induce a protein-calorie deficiency in the suckling pups. Control rats were offered a diet containing 25% casein. Suckling pups from these groups were then given by intubation either distilled water or isocaloric supplements containing either nonprotein calories or protein. A specific protein deficiency was thus successfully imposed on the suckling pups during this critical period for tooth development. Protein deficiency limited the growth of incisors and molars and delayed eruption, but had no effect on tooth mineral composition. Such tooth changes are of great significance as teeth are not capable of repairing and compensating for these effects which, consequently, may be responsible for the increased caries susceptibility previously demonstrated under the same experimental conditions.


KEY WORDS: • artificial feeding • calories • development • malnutrition • protein • teeth • suckling rats

1 Publication no. 2064 of the Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass. Supported by the National Institute of Dental Research (Program Project DE 02714-01). Doctor DiOrio was supported by a postdoctoral training fellowship provided by the National Institute of Dental Research, National Institutes of Health, Bethesda, Md.

2 Current address: The University of Texas, Dental Branch, P.O. Box 20068, Houston, Texas 77025.

3 Current address: Institute of Dental Research, University of Alabama in Birmingham, University Station, Birmingham, Ala. 35294.

Manuscript received 26 October 1972.


This article has been cited by other articles:


Home page
JDRHome page
J. M. Navia
Dr. Robert S. Harris: Nutritionist, Oral Science Researcher, and Visionary MIT Educator
Journal of Dental Research, March 1, 1998; 77(3): 438 - 444.
[Abstract] [PDF]


Home page
JDRHome page
J.O. Alvarez, J.C. Eguren, J. Caceda, and J.M. Navia
The Effect of Nutritional Status on the Age Distribution of Dental Caries in the Primary Teeth
Journal of Dental Research, September 1, 1990; 69(9): 1564 - 1566.
[Abstract] [PDF]


Home page
JDRHome page
T. Nakamoto, H. M. Mallek, and S. A. Miller
In vitro Collagen Synthesis of Tooth Germs from Newborn Rats with Protein-Energy Malnutrition
Journal of Dental Research, July 1, 1979; 58(7): 1717 - 1721.
[Abstract] [PDF]


Home page
JDRHome page
J.M. Navia and H. Lopez
Sources of Variability in Rat Caries Studies: Weaning Age and Diet Fed During Tooth Eruption
Journal of Dental Research, March 1, 1977; 56(3): 222 - 227.
[Abstract] [PDF]


Home page
JDRHome page
L. Menaker and J. M. Navia
Effect of Undernutrition During the Perinatal Period on Caries Development in the Rat: V. Changes in Whole Saliva Volume and Protein Content
Journal of Dental Research, May 1, 1974; 53(3): 592 - 597.
[Abstract] [PDF]




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 1973 by American Society for Nutrition