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Effect of Intravenous Gossypol Injection on Iron Utilization in Swine^{1 ,2}

Department of Animal Science, North Carolina State University, Raleigh, North Carolina 27607

Intravenous injection of gossypol in swine increased the concentration of iron in the liver and bile and decreased the levels of hemoglobin and hematocrit. It is postulated that gossypol reacts with iron in the liver, and the iron-gossypol complex is then excreted via the bile.

KEY WORDS: • gossypol • iron • utilization • swine

¹ Supported in part by Public Health Service Grant no. AM-07039. It is Paper no. 3873 of the Journal Series of the North Carolina State University Agricultural Experiment Station, Raleigh, N. C. Use of trade names in this publication does not imply endorsement of the products mentioned.

² The material in this paper will be presented to the graduate faculty of North Carolina State University by Charles L. Skutches in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Animal Science.

Manuscript received 26 September 1972.