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Effect of Diet and Weaning Age on in vitro Lipogenesis in Young Swine

Shell Development Company, Modesto, California 95352

We have studied glucose utilization by adipose tissue slices and the activity of a number of enzymes concerned with fat synthesis in order to evaluate the effects of chronological age, age of weaning and the accessibility of creep-feed upon the emergence of high rates of lipogenesis. Preweaning activities of all parameters were low, and there were some minor fluctuations. Two weeks after weaning, glucose incorporation into CO₂ or lipids was increased in animals weaned at 21 or 35 days, while animals weaned at 14 days had only marginal increases. Enzyme activities generally increased in the same manner with marginal increases observed in animals weaned at day 14. The adaptive pattern (to increased lipogenesis) was unique for each enzyme. Animals fed creep-feed generally had increased glucose incorporation into lipids, as well as increased enzyme activity (50 to 250% depending on the parameter) even though not yet weaned. The degree of adaptation to a high carbohydrate diet seems to depend not only upon the relative amounts of carbohydrate and lipid in the diet (milk or milk plus creep or starter ration) but also upon the age at which the animal is weaned.

KEY WORDS: • lipogenesis • glucose utilization • high carbohydrate diet • age

Manuscript received 24 July 1972.