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Effects of Long-term Administration of 2-Deoxy-D-glucose on Food Intake and Weight Gain in Rats¹

The First Department of Internal Medicine, School of Medicine, University of Tokyo, Bunkyo-Ku, Tokyo, Japan; The Central Laboratory, Kyorin Pharmaceutical Company, Ukima, Kita-Ku, Tokyo, Japan; and The Central Laboratory, Tokyo Tanabe Pharmaceutical Company, Akabane, Kita-Ku, Tokyo, Japan

Single intraperitoneal injections of 100 mg of 2-deoxy-D-glucose (2-DG) into about 180-g male rats, increased plasma glucose and decreased plasma free fatty acids and free glycerol, both in fasted and in ad libitum-fed rats. Daily morning injections increased daytime food consumption, but not night consumption, with consequent increases in daily food intake. However, weight gain of treated rats was not different from the control rats. When injections were discontinued, daytime food intake of treated rats promptly decreased to the level of the control rats, who maintained the previous food consumption level. However, when fed only during the daytime, injections did not influence food intake during this period. Body weight gains of both treated and control rats became almost identical, soon after the start of daytime feeding, with that of the previous period despite less daily food consumption. Evening 2-DG injections did not affect either food intake or weight gain during the night. This suggested that, although 100 mg of 2-DG increased daytime food intake when injected in the morning, the injection was not powerful enough to change the satiety center sensitivity when intrinsic requirements for food were great, and also suggested that body weight was not controlled only by the amount of food consumed.

KEY WORDS: • satiety center • 2-deoxy-D-glucose • food intake • plasma glucose • plasma free fatty acids • plasma free glycerol

¹ A preliminary report of these results was presented at the Symposium on Obesity held by the Japanese Medical Society in January, 1972 in Tokyo, Japan.

Manuscript received 30 October 1972.

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