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Influence of Food Intake Frequency on 26-¹⁴C-Cholesterol Turnover in Pullets Fed a Basal and Cholesterol-enriched Diet

P. Bobek, E. Ginter, J. Babala, J. erve, V. Peter and V. Chrappa

Institute of Human Nutrition Research, Bratislava, Institute for Poultry Research, Ivánka pri Dunaji and Department of Pathological Anatomy, Faculty of Medicine, J. A. Komensky's University, Bratislava

The influence of a meal-feeding regimen (two 1-hour periods daily) on pool and kinetic parameters of cholesterol metabolism was studied in pullets (ROSS I) fed a basal or a 0.5% cholesterol-enriched diet. For this purpose, the plasma cholesterol turnover curves 1 to 50 days after the intravenous administration of a single dose of 26-¹⁴C-cholesterol were subjected to a kinetic analysis in a two-pool model. In chickens fed the basal diet, meal-feeding shortened the plasma cholesterol half-time and raised fractional cholesterol turnover in the rapidly turning-over pool. In chickens fed the cholesterol-enriched diet, the plasma cholesterol half-time was longer and fractional cholesterol turnover was smaller, while the size of the rapidly turning-over cholesterol pool increased. The feeding frequency did not influence cholesterol catabolism or the plasma cholesterol level in either group (basal or cholesterol-enriched diet). Accordingly, the incidence and severity of atherosclerotic lesions in the aorta and myocardial coronary arteries of chickens fed ad libitum or 2 hours daily the cholesterol-enriched diet were only nonsignificantly greater.

KEY WORDS: • chicken • feeding frequency • cholesterol-26-¹⁴C turnover

Manuscript received 2 October 1972.