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Antiselenium Activity of Tri-o-cresyl Phosphate in Rats and Japanese Quail¹

Department of Animal Science, Oregon State University, Corvallis, Oregon 97331

Dietary administration of tri-ortho-cresyl phosphate (TOCP) to low selenium–low vitamin E Torula yeast based diets resulted in growth cessation and mortality in both rats and Japanese quail. Supplementation of the rat diets with various levels of either selenium or vitamin E prevented both growth cessation and mortality. Rats that had ceased growing following TOCP administration responded with renewed growth when the diet was supplemented with either vitamin E or selenium; the response to selenium was significantly greater than the response to vitamin E, suggesting that TOCP may be a selenium antagonist. There was a slight tendency for TOCP to increase the specific activity of lipase in pancreatic homogenates. With TOCP-fed Japanese quail, the gains were significantly greater and the mortality lower when selenium was supplemented than when vitamin E was added. The results in both rats and Japanese quail suggest that TOCP antagonizes selenium as well as vitamin E.

KEY WORDS: • rats • Japanese quail • selenium • vitamin E • tri-o-cresyl phosphate

¹ Oregon Agricultural Experiment Station Technical Paper no. 3436.

Manuscript received 2 October 1972.