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Effect of Infused Glutamine on Uric Acid Synthesis in Chickens Fed High and Low Protein Diets

Laboratory of Animal Nutrition, Faculty of Agriculture, Nagoya University, Nagoya 464, Japan

This study was carried out to clarify the physiological role of glutamine in uric acid synthesis in the metabolic process of chickens. The feeding of a high (20%) protein diet resulted in higher concentration of plasma uric acid and lower concentration of plasma glutamine than the feeding of a low (5%) protein diet. This phenomenon seems to result from the rapid conversion of glutamine to uric acid. Glutamine infused into chickens fed the high protein diet caused an increase in urinary uric acid and a rapid rise in plasma uric acid concentration. However, for chickens fed the low protein diet, glutamine infusion did not affect urinary uric acid excretion but did cause a delayed elevation of plasma uric acid concentration. The accumulation of plasma glutamine in the blood during infusion was significantly smaller when the high protein diet than when the low protein diet was fed. These results indicate that the induction of uric acid synthesis by glutamine infusion is more rapid in chickens fed a high protein diet than in those fed a low protein diet.

KEY WORDS: • glutamine infusion • protein level • chicken • uric acid synthesis

Manuscript received 18 September 1972.