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Changes in Tissue Magnesium, Calcium and Phosphorus Levels in Magnesium-deficient Rats in Relation to Thiamin Excess or Deficiency1

Yoshinori Itokawa and Motonori Fujiwara

Department of Hygiene, Faculty of Medicine, Kyoto University, Kyoto, Japan

To clarify the influence of thiamin deficiency or a dietary excess of thiamin on magnesium, calcium and phosphorus levels in serum and various tissues, the following six different synthetic diets were fed to Wistar rats. Group 1: thiamin and magnesium deficient; group 2: thiamin deficient, magnesium sufficient; group 3: thiamin sufficient, magnesium deficient; group 4: thiamin sufficient, magnesium sufficient; group 5: thiamin excess, magnesium deficient; group 6: thiamin excess, magnesium sufficient. Rats were killed after 4 weeks and the levels of magnesium, calcium and phosphorus in serum and various tissues were determined. The changes observed in magnesium-deficient groups (groups 1, 3 and 5) are characterized as follows: magnesium levels in serum, bone, muscles and heart decreased; calcium levels in serum, muscles, heart and kidneys increased and, in contrast, calcium levels in bone decreased; serum and bone phosphorus decreased. These changes in thiamin-sufficient, magnesium-deficient rats (groups 3 and 5) are greater than in rats deficient in both thiamin and magnesium (group 1).

KEY WORDS: • magnesium • calcium • phosphorus • thiamin

1 Supported by Research Grants no. 8428 and no. 767088 from the Ministry of Education, Japan.

Manuscript received 28 August 1972.




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