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Influence of Dietary Protein Level on Plasma Cholesterol Turnover and Fecal Steroid Excretion in the Chick¹

Laboratory of Nutritional Biochemistry, Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

The turnover rate of plasma cholesterol in chicks fed 30% or 15% protein diets was investigated by administering cholesterol-4-¹⁴C and periodically determining the specific activity of plasma cholesterol. Fecal steroid excretion was also determined. The results indicate that the turnover rate of plasma cholesterol is higher in chicks fed a high protein diet compared with those fed a low protein diet. It is concluded that the hypocholesterolemic effect of dietary protein is mediated in part through a more rapid removal of cholesterol from the blood and excretion in the feces as cholesterol and bile acids.

KEY WORDS: • cholesterol • diet • protein • chick • sterol • bile acid

¹ Supported in part by Public Health Service Grant HL-14677 from the Heart and Lung Institute.

² Present address: 204 Food Science Building, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48828.

Manuscript received 23 August 1972.