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Further Purification and Mode of Action of a Goitrogenic Material from Soybean Flour¹

Department of Nutrition, Hebrew University-Hadassah Medical School, Jerusalem, Israel

A goitrogenic substance in soya beans has been further purified and characterized. It is a compound of low molecular weight, probably an oligopeptide composed of two or three amino acids or a glycopeptide consisting of one or two amino acids and a sugar. It inhibits iodine uptake by the thyroid in vivo and in vitro and decreases its organification by the gland. Thyroid glands exposed in vitro to the agent incorporate relatively less radioiodine into diiodotyrosine than controls. The ratio of radioiodinated triiodothyronine to thyroxine is increased in these glands.

KEY WORDS: • thyroid • iodine • soya beans

¹ Supported by a grant from the U. S. Department of Agriculture under P.L.480.

Manuscript received 31 July 1972.