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Effect of Various Carbohydrates in a Repletion Diet after Protein Depletion on Liver Lipid Content of Rats

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Furo-cho, Chikusa, Nagoya, Japan

The effects of shifting from a protein-free diet to a protein repletion diet containing various types of carbohydrates on the liver lipid content were studied. Feeding a protein-free diet for 14 days followed by the feeding of a protein-repletion diet containing sucrose or fructose, but not starch, dextrin or glucose as the sole carbohydrate source caused the accumulation of liver lipids, although the amount of food consumed by rats fed repletion diets containing various types of carbohydrates for 3 or 6 days was similar except when starch was fed. Furthermore, the liver lipid level of rats fed the repletion diet containing sucrose tended to be lower than when fructose was fed, whereas liver lipid content of rats fed a diet containing fructose was higher than that of rats fed a diet containing glucose without previously feeding a protein-free diet. However, its levels were not so high as to produce fatty liver as observed in the case of feeding a protein repletion diet containing sucrose or fructose after protein depletion. Thus, it seemed reasonable to assume that at least two factors are responsible for the accumulation of lipids in the liver:

1) pretreatment of rats with a protein-free diet and

2) the presence of fructose in the protein repletion diet.

KEY WORDS: • carbohydrate • liver lipid content • protein-free diet

Manuscript received 15 May 1972.