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Effect of Dietary Protein on the Intestinal Biosynthesis of Retinol from ¹⁴C-ß-carotene in Rats^1,2,3,

Department of Food and Nutrition, Iowa State University, Ames, Iowa 50010

The influence of dietary protein on intestinal biosynthesis of retinol from ¹⁴C-ß-carotene in rats was investigated. During the digestive phase, a dose of 20 µg of biosynthetically labeled ¹⁴C-ß-carotene was injected into the unligated upper intestine. After 2.5 hours, radioactivity incorporated into the retinyl ester fraction of the intestine was 2.7% of the injected dose in animals fed a 10% protein diet. With a 40% protein diet, the comparable value was 5.9%. There was more newly deposited hepatic retinol at higher levels of dietary protein. The data support indirect evidence, obtained in previous experiments, that the intestinal wall is an important site for the carotene-protein interaction.

KEY WORDS: • carotene • retinyl ester • protein • intestine

¹ Journal Paper no. J-7188 Iowa Agriculture and Home Economics Experiment Station, Ames, Iowa, Project no. 1895.

² Research was funded in part by National Institutes of Health Grant no. AM-07713.

³ This work was presented at the meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N. J., April, 1970, Federation Proc. 29: 264 (abstr.).

⁴ Present address: School of Associated Medical Science, University of Illinois Medical Center, Chicago, Ill.

Manuscript received 20 March 1972.