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Effects of Large Doses of Vitamin C in Guinea Pigs and Rats1

B. K. Nandi, A. K. Majumder, N. Subramanian and I. B. Chatterjee

Department of Biochemistry, University College of Science, Calcutta-19, India

Large doses of ascorbic acid had neither beneficial nor toxic effect on growth and maintenance of rats and guinea pigs fed a nutritionally balanced fortified wheat diet. However, a daily intake of 50 mg or more ascorbic acid was toxic to guinea pigs fed unfortified wheat diet. Supplementation of the unfortified wheat diet by casein counteracted the toxicity of large doses of ascorbic acid.

KEY WORDS: • ascorbic acid excess • guinea pig growth • rat pregnancy • ascorbic acid storage • fortified wheat diet • lysine

1 The work was supported by PL-480 project no. A7-HN-25, Grant no. FG-In-416.

Manuscript received 24 May 1973.




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Copyright © 1973 by American Society for Nutrition