QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Allen, L. H. Articles by Zeman, F. J. Search for Related Content PubMed PubMed Citation Articles by Allen, L. H. Articles by Zeman, F. J.

Kidney Function in the Progeny of Protein-deficient Rats¹

Department of Nutrition, University of California, Davis, California 95616

Kidney function was evaluated in the progeny of rats fed a proteindeficient (6% casein) diet compared to those of rats fed a control (24% casein) diet throughout gestation. Control and deficient progeny were raised together by foster mothers in either normal-sized litters of 10 pups, or in small-sized litters of four pups in which they received increased nutrient intake. The ability to excrete a water load or to respond to ADH was impaired in the deficient progeny at 6 days after birth, but not at 13 days. Increased postnatal nutrient intake partially compensated for these reductions in function. Clomerular filtration rate and maximal tubular secretory capacity were significantly reduced in 22-day-old deficient animals. On a body weight basis increased postnatal nutrient intake produced a significant increase only in glomerular filtration rate of deficient animals. These reductions of function in deficient progeny are probably related to decreased nephron number caused by the prenatal deficiency.

KEY WORDS: • kidney function • prenatal • protein deprivation

¹ Supported in part by Public Health Research Grant no. HD-03158 from the National Institute of Child Health and Human Development.

² To whom reprint requests should be sent.

Manuscript received 20 April 1973.