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Journal of Nutrition Vol. 103 No. 10 October 1973, pp. 1448-1453
Copyright © 1973 by American Society for Nutrition
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Inositol Deficiency in Gerbils: Dietary Effects on the INtestinal Lipodystrophy1

J. F. Kroes, D. M. Hegsted and K. C. Hayes

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115

The effects of coconut oil, partially purified triglycerides, and dietary cholesterol on the induction of the intestinal lipodystrophy were investigated in female gerbils fed diets low in inositol. When the inositol-deficient diet was fed with saturated triglycerides, maximal gut lipid was found with triglycerides rich in lauric acid (12:0) and somewhat less with those rich in capric acid (10:0) and myristic acid (14:0), these being the major fatty acids in coconut oil. Increasing chain length decreased the accumulation of gut lipid. No excess was found with triglycerides rich in caprylic acid (8:0), presumably absorbed through the portal system, or with stearic acid (18:0). The latter, however, was poorly absorbed. Unsaturated triglycerides rich in oleic or linoleic acids (18:1 {omega} 9 and 18:2 {omega} 6) also produced no accumulation of gut lipid. Feeding 0.2 to 0.5% of cholesterol accentuated the lipodystrophy, but this was prevented by inositol. The resistance of male gerbils to the lipodystrophy was eliminated by castration, indicating that testicular synthesis of inositol was a major factor in the difference between male and female gerbils.

KEY WORDS: • inositol • intestinal lipodystrophy • saturated fatty acids • lipid metabolism

1 Supported in part by Public Health Service Research Grants HE-12399 and K6-AM-18455, a Post-doctoral Research Fellowship (1-FO2-AM-52,728-01) from the National Institute of Arthritis and Metabolic Disease (Dr. Kroes), and the Fund for Research and Teaching. Department of Nutrition, Harvard School of Public Health.

Manuscript received 27 March 1973.




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